Gene Expression Profiling Reveals that PXR Activation Inhibits Hepatic PPARα Activity and Decreases FGF21 Secretion in Male C57Bl6/J Mice

The pregnane X receptor (PXR) is the main nuclear receptor regulating the expression of xenobiotic-metabolizing enzymes and is highly expressed in the liver and intestine. Recent studies have highlighted its additional role in lipid homeostasis, however, the mechanisms of these regulations are not f...

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Udgivet i:Int J Mol Sci
Main Authors: Barretto, Sharon Ann, Lasserre, Frédéric, Fougerat, Anne, Smith, Lorraine, Fougeray, Tiffany, Lukowicz, Céline, Polizzi, Arnaud, Smati, Sarra, Régnier, Marion, Naylies, Claire, Bétoulières, Colette, Lippi, Yannick, Guillou, Hervé, Loiseau, Nicolas, Gamet-Payrastre, Laurence, Mselli-Lakhal, Laila, Ellero-Simatos, Sandrine
Format: Artigo
Sprog:Inglês
Udgivet: MDPI 2019
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6696478/
https://ncbi.nlm.nih.gov/pubmed/31374856
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms20153767
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