Inhibition of UCH-L1 Deubiquitinating Activity with Two Forms of LDN-57444 Has Anti-Invasive Effects in Metastatic Carcinoma Cells

Normally ubiquitin C-terminal hydrolase L1 (UCH-L1) is expressed in the central nervous and reproductive systems of adults, but its de novo expression has been detected in many human cancers. There is a growing body of evidence that UCH-L1 de-ubiquitinating (DUB) activity plays a major pro-metastati...

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Publicado en:Int J Mol Sci
Autores principales: Kobayashi, Eiji, Hwang, Duhyeong, Bheda-Malge, Anjali, Whitehurst, Christopher B., Kabanov, Alexander V., Kondo, Satoru, Aga, Mitsuharu, Yoshizaki, Tomokazu, Pagano, Joseph S., Sokolsky, Marina, Shakelford, Julia
Formato: Artigo
Lenguaje:Inglês
Publicado: MDPI 2019
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6696221/
https://ncbi.nlm.nih.gov/pubmed/31370144
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms20153733
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