Highly Efficient Generation of Pigs Harboring a Partial Deletion of the CD163 SRCR5 Domain, Which Are Fully Resistant to Porcine Reproductive and Respiratory Syndrome Virus 2 Infection

Porcine reproductive and respiratory syndrome virus (PRRSV) 1 and 2 differ in their recognition of CD163. Substitution of porcine CD163 SRCR5 domain with a human CD163-like SRCR8 confers resistance to PRRSV 1 but not PRRSV 2. The deletion of CD163 SRCR5 has been shown to confer resistance to PRRSV 1...

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Gepubliceerd in:Front Immunol
Hoofdauteurs: Guo, Chunhe, Wang, Min, Zhu, Zhenbang, He, Sheng, Liu, Hongbo, Liu, Xiaofeng, Shi, Xuan, Tang, Tao, Yu, Piao, Zeng, Jianhua, Yang, Linfang, Cao, Yongchang, Chen, Yaosheng, Liu, Xiaohong, He, Zuyong
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Frontiers Media S.A. 2019
Onderwerpen:
Immunology
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6694839/
https://ncbi.nlm.nih.gov/pubmed/31440241
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2019.01846
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