Interleukin-8 Secreted by Glioblastoma Cells Induces Microvascular Hyperpermeability Through NO Signaling Involving S-Nitrosylation of VE-Cadherin and p120 in Endothelial Cells

Glioblastoma is a highly aggressive brain tumor, characterized by the formation of dysfunctional blood vessels and a permeable endothelial barrier. S-nitrosylation, a post-translational modification, has been identified as a regulator of endothelial function. In this work we explored whether S-nitro...

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Veröffentlicht in:Front Physiol
Hauptverfasser: Guequén, Anita, Zamorano, Patricia, Córdova, Francisco, Koning, Tania, Torres, Angelo, Ehrenfeld, Pamela, Boric, Mauricio P., Salazar-Onfray, Flavio, Gavard, Julie, Durán, Walter N., Quezada, Claudia, Sarmiento, José, Sánchez, Fabiola A.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Frontiers Media S.A. 2019
Schlagworte:
Physiology
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6694439/
https://ncbi.nlm.nih.gov/pubmed/31440166
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphys.2019.00988
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