3D Monte Carlo bone marrow dosimetry for Lu-177-PSMA therapy with guidance of non-invasive 3D localization of active bone marrow via Tc-99m-anti-granulocyte antibody SPECT/CT

BACKGROUND: The bone marrow (BM) is a main risk organ during Lu-177-PSMA ligand therapy of metastasized castration-resistant prostate cancer (mCRPC) patients. So far, BM dosimetry relies on S values, which are pre-computed for reference anatomies, simplified activity distributions, and a physiologic...

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Detalhes bibliográficos
Publicado no:EJNMMI Res
Main Authors: Gosewisch, Astrid, Ilhan, Harun, Tattenberg, Sebastian, Mairani, Andrea, Parodi, Katia, Brosch, Julia, Kaiser, Lena, Gildehaus, Franz Josef, Todica, Andrei, Ziegler, Sibylle, Bartenstein, Peter, Böning, Guido
Formato: Artigo
Idioma:Inglês
Publicado em: Springer Berlin Heidelberg 2019
Assuntos:
Original Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6694348/
https://ncbi.nlm.nih.gov/pubmed/31414241
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13550-019-0548-z
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