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Identification of mutations in HEXA and HEXB in Sandhoff and Tay-Sachs diseases: a new large deletion caused by Alu elements in HEXA

G(M2) gangliosides are a group of lysosomal lipid storage disorders that are due to mutations in HEXA, HEXB and GM2A. In our study, 10 patients with these diseases were enrolled, and Sanger sequencing was performed for the HEXA and HEXB genes. The results revealed one known splice site mutation (c.3...

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Bibliografski detalji
Izdano u:Hum Genome Var
Glavni autori: Dastsooz, Hassan, Alipour, Mohsen, Mohammadi, Sanaz, Kamgarpour, Fatemeh, Dehghanian, Fatemeh, Fardaei, Majid
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group 2018
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6694291/
https://ncbi.nlm.nih.gov/pubmed/31428437
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/hgv.2018.3
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