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Flux balance analysis with or without molecular crowding fails to predict two thirds of experimentally observed epistasis in yeast
Computational predictions of double gene knockout effects by flux balance analysis (FBA) have been used to characterized genome-wide patterns of epistasis in microorganisms. However, it is unclear how in silico predictions are related to in vivo epistasis, as FBA predicted only a minority of experim...
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| Veröffentlicht in: | Sci Rep |
|---|---|
| Hauptverfasser: | , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Nature Publishing Group UK
2019
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6694147/ https://ncbi.nlm.nih.gov/pubmed/31413270 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-47935-6 |
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