Intrabody against prolyl hydroxylase 2 promotes angiogenesis by stabilizing hypoxia-inducible factor-1α

Hypoxia-inducible factor (HIF)-1α is a crucial transcription factor that regulates the expression of target genes involved in angiogenesis. Prolyl hydroxylase 2 (PHD2) dominantly hydroxylates two highly conserved proline residues of HIF-1α to promote its degradation. This study was designed to const...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Sci Rep
Egile Nagusiak: Zhao, Liangzhong, Liu, Ziyu, Yang, Fang, Zhang, Ying, Xue, Ying, Miao, Haipeng, Liao, Xiangzhi, Huang, Hongli, Li, Guiying
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Nature Publishing Group UK 2019
Gaiak:
Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC6694103/
https://ncbi.nlm.nih.gov/pubmed/31413262
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-47891-1
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