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Driving Recursive Dehydration by P(III)/P(V) Catalysis: Annulation of Amines and Carboxylic Acids by Sequential C–N and C–C Bond Formation

[Image: see text] A method for the annulation of amines and carboxylic acids to form pharmaceutically relevant azaheterocycles via organophosphorus P(III)/P(V) redox catalysis is reported. The method employs a phosphetane catalyst together with a mild bromenium oxidant and terminal hydrosilane reduc...

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Bibliografiske detaljer
Udgivet i:J Am Chem Soc
Main Authors: Lecomte, Morgan, Lipshultz, Jeffrey M., Kim-Lee, Shin-Ho, Li, Gen, Radosevich, Alexander T.
Format: Artigo
Sprog:Inglês
Udgivet: American Chemical Society 2019
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6693942/
https://ncbi.nlm.nih.gov/pubmed/31345031
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.9b06277
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