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Deep generative models of genetic variation capture the effects of mutations
The functions of proteins and RNAs are defined by the collective interactions of many residues, and yet most statistical models of biological sequences consider sites nearly independently. Recent approaches have demonstrated benefits of including interactions to capture pairwise covariation, but lea...
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| Udgivet i: | Nat Methods |
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| Main Authors: | , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2018
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6693876/ https://ncbi.nlm.nih.gov/pubmed/30250057 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41592-018-0138-4 |
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