Dysregulated claudin-5 cycling in the inner retina causes retinal pigment epithelial cell atrophy

Age-related macular degeneration (AMD) is the leading cause of central retinal vision loss worldwide, with an estimated 1 in 10 people over the age of 55 showing early signs of the condition. There are currently no forms of therapy available for the end stage of dry AMD, geographic atrophy (GA). Her...

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Udgivet i:JCI Insight
Main Authors: Hudson, Natalie, Celkova, Lucia, Hopkins, Alan, Greene, Chris, Storti, Federica, Ozaki, Ema, Fahey, Erin, Theodoropoulou, Sofia, Kenna, Paul F., Humphries, Marian M., Curtis, Annie M., Demmons, Eleanor, Browne, Akeem, Liddie, Shervin, Lawrence, Matthew S., Grimm, Christian, Cahill, Mark T., Humphries, Pete, Doyle, Sarah L., Campbell, Matthew
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Clinical Investigation 2019
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6693834/
https://ncbi.nlm.nih.gov/pubmed/31391341
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.130273
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