Protein Kinase Cι and Wnt/β-catenin signaling: Alternative pathways to Kras/Trp53 driven lung adenocarcinoma

We report that mouse LSL-Kras(G12D);Trp53(fl/fl) (KP)-mediated lung adenocarcinoma (LADC) tumorigenesis can proceed through both PKCι-dependent and PKCι-independent pathways. The predominant pathway involves PKCι-dependent transformation of bronchioalveolar stem cells (BASCs). However, KP mice harbo...

Descripció completa

Guardat en:
Dades bibliogràfiques
Publicat a:Cancer Cell
Autors principals: Yin, Ning, Liu, Yi, Khoor, Andras, Wang, Xue, Thompson, E. Aubrey, Leitges, Michael, Justilien, Verline, Weems, Capella, Murray, Nicole R., Fields, Alan P.
Format: Artigo
Idioma:Inglês
Publicat: 2019
Matèries:
Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6693680/
https://ncbi.nlm.nih.gov/pubmed/31378680
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccell.2019.07.002
Etiquetes: Afegir etiqueta
Sense etiquetes, Sigues el primer a etiquetar aquest registre!

Ítems similars