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Lowering Lipophilicity by Adding Carbon: AzaSpiroHeptanes, a logD Lowering Twist
[Image: see text] We have conducted an analysis of azaspiro[3.3]heptanes used as replacements for morpholines, piperidines, and piperazines in a medicinal chemistry context. In most cases, introducing a spirocyclic center lowered the measured logD(7.4) of the corresponding molecules by as much as −1...
में बचाया:
| में प्रकाशित: | ACS Med Chem Lett |
|---|---|
| मुख्य लेखकों: | , , |
| स्वरूप: | Artigo |
| भाषा: | Inglês |
| प्रकाशित: |
American Chemical
Society
2019
|
| ऑनलाइन पहुंच: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6693472/ https://ncbi.nlm.nih.gov/pubmed/31417667 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.9b00248 |
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