Exploratory proteomic analysis implicates the alternative complement cascade in primary CNS vasculitis

OBJECTIVE: To identify molecular correlates of primary angiitis of the CNS (PACNS) through proteomic analysis of CSF from a biopsy-proven patient cohort. METHODS: Using mass spectrometry, we quantitatively compared the CSF proteome of patients with biopsy-proven PACNS (n = 8) to CSF from individuals...

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Published in:Neurology
Main Authors: Mandel-Brehm, Caleigh, Retallack, Hanna, Knudsen, Giselle M., Yamana, Alex, Hajj-Ali, Rula A., Calabrese, Leonard H., Tihan, Tarik, Sample, Hannah A., Zorn, Kelsey C., Gorman, Mark P., Madan Cohen, Jennifer, Sreih, Antoine G., Marcus, Jacqueline F., Josephson, S. Andrew, Douglas, Vanja C., Gelfand, Jeffrey M., Wilson, Michael R., DeRisi, Joseph L.
Format: Artigo
Language:Inglês
Published: Lippincott Williams & Wilkins 2019
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6693432/
https://ncbi.nlm.nih.gov/pubmed/31270218
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1212/WNL.0000000000007850
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