Immune microenvironment modulation unmasks therapeutic benefit of radiotherapy and checkpoint inhibition

BACKGROUND: Immune checkpoint inhibitors (ICIs) for solid tumors, including those targeting programmed cell death 1 (PD-1) and cytotoxic T lymphocyte-associated antigen 4 (CTLA-4), have shown impressive clinical efficacy, however, most patients do not achieve durable responses. One major therapeutic...

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Detalhes bibliográficos
Publicado no:J Immunother Cancer
Main Authors: Newton, Jared M., Hanoteau, Aurelie, Liu, Hsuan-Chen, Gaspero, Angelina, Parikh, Falguni, Gartrell-Corrado, Robyn D., Hart, Thomas D., Laoui, Damya, Van Ginderachter, Jo A., Dharmaraj, Neeraja, Spanos, William C., Saenger, Yvonne, Young, Simon, Sikora, Andrew G.
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2019
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6693252/
https://ncbi.nlm.nih.gov/pubmed/31409394
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40425-019-0698-6
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