Phf6-null hematopoietic stem cells have enhanced self-renewal capacity and oncogenic potentials

Plant homeodomain finger gene 6 (PHF6) encodes a 365-amino-acid protein containing 2 plant homology domain fingers. Germline mutations of human PHF6 cause Börjeson-Forssman-Lehmann syndrome, a congenital neurodevelopmental disorder. Loss-of-function mutations of PHF6 are detected in patients with ac...

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Udgivet i:Blood Adv
Main Authors: Hsu, Yueh-Chwen, Chen, Tsung-Chih, Lin, Chien-Chin, Yuan, Chang-Tsu, Hsu, Chia-Lang, Hou, Hsin-An, Kao, Chein-Jun, Chuang, Po-Han, Chen, Yu-Ren, Chou, Wen-Chien, Tien, Hwei-Fang
Format: Artigo
Sprog:Inglês
Udgivet: American Society of Hematology 2019
Fag:
Hematopoiesis and Stem Cells
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6693005/
https://ncbi.nlm.nih.gov/pubmed/31395598
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/bloodadvances.2019000391
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