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Doxorubicin induces detrusor smooth muscle impairments through myosin dysregulation, leading to a risk of lower urinary tract dysfunction

Cytotoxic chemotherapy is the foundation for the treatment of the wide variety of childhood malignancies; however, these therapies are known to have a variety of deleterious side effects. One common chemotherapy used in children, doxorubicin (DOX), is well known to cause cardiotoxicity and cardiomyo...

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Publicat a:Am J Physiol Renal Physiol
Autors principals: Iguchi, Nao, Dönmez, M. İrfan, Carrasco, Alonso, Wilcox, Duncan T., Pineda, Ricardo H., Malykhina, Anna P., Cost, Nicholas G.
Format: Artigo
Idioma:Inglês
Publicat: American Physiological Society 2019
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6692723/
https://ncbi.nlm.nih.gov/pubmed/31066574
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajprenal.00090.2019
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