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Allostery in G Protein-Coupled Receptors Investigated by Molecular Dynamics Simulations
G-protein-coupled receptors (GPCRs) are allosteric signaling machines that trigger distinct functional responses depending on the particular conformational state they adopt upon binding. This so-called GPCR functional selectivity is prompted by ligands of different efficacy binding at orthosteric or...
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| Vydáno v: | Curr Opin Struct Biol |
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| Hlavní autoři: | , |
| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
2019
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6692184/ https://ncbi.nlm.nih.gov/pubmed/31096158 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.sbi.2019.03.016 |
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