Generation of human fatty livers using custom-engineered induced pluripotent stem cells with modifiable SIRT1 metabolism

The mechanisms by which steatosis of the liver progresses to non-alcoholic steatohepatitis, and end-stage liver disease remain elusive. Metabolic derangements in hepatocytes controlled by SIRT1 plays a role in the development of fatty liver in inbred-animals. The ability to perform similar studies u...

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Detalhes bibliográficos
Publicado no:Cell Metab
Main Authors: Collin de l’Hortet, Alexandra, Takeishi, Kazuki, Guzman-Lepe, Jorge, Morita, Kazutoyo, Achreja, Abhinav, Popovic, Branimir, Wang, Yang, Handa, Kan, Mittal, Anjali, Meurs, Noah, Zhu, Ziwen, Weinberg, Frank, Salomon, Michael, Fox, Ira J, Deng, Chu-Xia, Nagrath, Deepak, Soto-Gutierrez, Alejandro
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6691905/
https://ncbi.nlm.nih.gov/pubmed/31390551
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cmet.2019.06.017
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