Preoperative administration of the 5-HT4 receptor agonist prucalopride reduces intestinal inflammation and shortens postoperative ileus via cholinergic enteric neurons

OBJECTIVES: Vagus nerve stimulation (VNS), most likely via enteric neurons, prevents postoperative ileus (POI) by reducing activation of alpha7 nicotinic receptor (α7nAChR) positive muscularis macrophages (mMφ) and dampening surgery-induced intestinal inflammation. Here, we evaluated if 5-HT4 recept...

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Detalhes bibliográficos
Publicado no:Gut
Main Authors: Stakenborg, Nathalie, Labeeuw, Evelien, Gomez-Pinilla, Pedro J, De Schepper, Sebastiaan, Aerts, Raymond, Goverse, Gera, Farro, Giovanna, Appeltans, Iris, Meroni, Elisa, Stakenborg, Michelle, Viola, Maria Francesca, Gonzalez-Dominguez, Erika, Bosmans, Goele, Alpizar, Yeranddy A, Wolthuis, Albert, D’Hoore, Andre, Van Beek, Kim, Verheijden, Simon, Verhaegen, Marleen, Derua, Rita, Waelkens, Etienne, Moretti, Milena, Gotti, Cecilia, Augustijns, Patrick, Talavera, Karel, Vanden Berghe, Pieter, Matteoli, Gianluca, Boeckxstaens, Guy E
Formato: Artigo
Idioma:Inglês
Publicado em: BMJ Publishing Group 2019
Assuntos:
Neurogastroenterology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6691854/
https://ncbi.nlm.nih.gov/pubmed/30472681
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/gutjnl-2018-317263
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