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Redox Cofactor Rotates during Its Stepwise Decarboxylation: Molecular Mechanism of Conversion of Coproheme to Heme b

[Image: see text] Coproheme decarboxylase (ChdC) catalyzes the last step in the heme biosynthesis pathway of monoderm bacteria with coproheme acting both as redox cofactor and substrate. Hydrogen peroxide mediates the stepwise decarboxylation of propionates 2 and 4 of coproheme. Here we present the...

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Vydáno v:ACS Catal
Hlavní autoři: Milazzo, Lisa, Gabler, Thomas, Pühringer, Dominic, Jandova, Zuzana, Maresch, Daniel, Michlits, Hanna, Pfanzagl, Vera, Djinović-Carugo, Kristina, Oostenbrink, Chris, Furtmüller, Paul G., Obinger, Christian, Smulevich, Giulietta, Hofbauer, Stefan
Médium: Artigo
Jazyk:Inglês
Vydáno: American Chemical Society 2019
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6691569/
https://ncbi.nlm.nih.gov/pubmed/31423350
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acscatal.9b00963
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