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In Vitro Assessment of Putative PD-1/PD-L1 Inhibitors: Suggestions of an Alternative Mode of Action

[Image: see text] The programmed cell death protein 1 (PD-1) signaling axis is among the most important therapeutic targets in modern oncology. Aurigene Discovery Technologies Ltd. (Aurigene) has patented a series of peptidomimetic small molecules derived from the PD-1 protein sequence for use in ta...

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Publicat a:ACS Med Chem Lett
Autors principals: Blevins, Derek J., Hanley, Ronan, Bolduc, Trevor, Powell, David A., Gignac, Michael, Walker, Kayleigh, Carr, Mark D., Hof, Fraser, Wulff, Jeremy E.
Format: Artigo
Idioma:Inglês
Publicat: American Chemical Society 2019
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6691557/
https://ncbi.nlm.nih.gov/pubmed/31413804
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.9b00221
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