Repurposing Brigatinib for the Treatment of Colorectal Cancer Based on Inhibition of ER-phagy

Rationale: The sustained and severe endoplasmic reticulum (ER) stress in cancer cells may contribute to apoptotic cell death, thus representing a potential target for cancer therapy. Brigatinib is an anaplastic lymphoma kinase (ALK) inhibitor approved for the treatment of ALK-positive non-small-cell...

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Bibliografiske detaljer
Udgivet i:Theranostics
Main Authors: Zhang, Zhe, Gao, Wei, Zhou, Li, Chen, Yan, Qin, Siyuan, Zhang, Lu, Liu, Jiayang, He, Yujia, Lei, Yunlong, Chen, Hai-Ning, Han, Junhong, Zhou, Zong-Guang, Nice, Edouard C., Li, Changlong, Huang, Canhua, Wei, Xiawei
Format: Artigo
Sprog:Inglês
Udgivet: Ivyspring International Publisher 2019
Fag:
Research Paper
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6691391/
https://ncbi.nlm.nih.gov/pubmed/31410188
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7150/thno.36254
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