Analysis of circulating cell-free DNA identifies KRAS copy number gain and mutation as a novel prognostic marker in Pancreatic cancer

Serial biopsy of pancreatic ductal adenocarcinoma (PDAC), to chart tumour evolution presents a significant challenge. We examined the utility of circulating free DNA (cfDNA) as a minimally invasive approach across a cohort of 55 treatment-naïve patients with PDAC; 31 with metastatic and 24 with loca...

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Publicado en:Sci Rep
Autores principales: Mohan, Sumitra, Ayub, Mahmood, Rothwell, Dominic G., Gulati, Sakshi, Kilerci, Bedirhan, Hollebecque, Antoine, Sun Leong, Hui, Smith, Nigel K., Sahoo, Sudhakar, Descamps, Tine, Zhou, Cong, Hubner, Richard A., McNamara, Mairéad G., Lamarca, Angela, Valle, Juan W., Dive, Caroline, Brady, Ged
Formato: Artigo
Lenguaje:Inglês
Publicado: Nature Publishing Group UK 2019
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6690979/
https://ncbi.nlm.nih.gov/pubmed/31406261
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-47489-7
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