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Synergistic silencing of α-globin and induction of γ-globin by histone deacetylase inhibitor, vorinostat as a potential therapy for β-thalassaemia

β-Thalassaemia is one of the most common monogenic diseases with no effective cure in the majority of patients. Unbalanced production of α-globin in the presence of defective synthesis of β-globin is the primary mechanism for anaemia in β-thalassaemia. Clinical genetic data accumulated over three de...

पूर्ण विवरण

में बचाया:
ग्रंथसूची विवरण
में प्रकाशित:Sci Rep
मुख्य लेखकों: Mettananda, Sachith, Yasara, Nirmani, Fisher, Christopher A., Taylor, Stephen, Gibbons, Richard, Higgs, Doug
स्वरूप: Artigo
भाषा:Inglês
प्रकाशित: Nature Publishing Group UK 2019
विषय:
ऑनलाइन पहुंच:https://ncbi.nlm.nih.gov/pmc/articles/PMC6690964/
https://ncbi.nlm.nih.gov/pubmed/31406232
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-48204-2
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