TGR(mREN2)27 rats develop non-alcoholic fatty liver disease-associated portal hypertension responsive to modulations of Janus-kinase 2 and Mas receptor

Prevalence of non-alcoholic fatty liver disease (NAFLD) is increasing. Resulting fibrosis and portal hypertension, as a possible secondary event, may necessitate treatment. Overexpression of mouse renin in the transgenic rat model, TGR(mREN2)27, leads to spontaneous development of NAFLD. Therefore,...

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Published in:Sci Rep
Main Authors: Klein, Sabine, Kleine, Carola-Ellen, Pieper, Andrea, Granzow, Michaela, Gautsch, Sebastian, Himmit, Mimoun, Kahrmann, Katharina, Schierwagen, Robert, Uschner, Frank Erhard, Magdaleno, Fernando, Naoum, Maria Eleni, Kristiansen, Glen, Walther, Thomas, Bader, Michael, Sauerbruch, Tilman, Trebicka, Jonel
Format: Artigo
Language:Inglês
Published: Nature Publishing Group UK 2019
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6690919/
https://ncbi.nlm.nih.gov/pubmed/31406138
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-48024-4
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