Hydrogen sulfide perturbs mitochondrial bioenergetics and triggers metabolic reprogramming in colon cells

Unlike most other tissues, the colon epithelium is exposed to high levels of H(2)S derived from gut microbial metabolism. H(2)S is a signaling molecule that modulates various physiological effects. It is also a respiratory toxin that inhibits complex IV in the electron transfer chain (ETC). Colon ep...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:J Biol Chem
Main Authors: Libiad, Marouane, Vitvitsky, Victor, Bostelaar, Trever, Bak, Daniel W., Lee, Ho-Joon, Sakamoto, Naoya, Fearon, Eric, Lyssiotis, Costas A., Weerapana, Eranthie, Banerjee, Ruma
Format: Artigo
Jezik:Inglês
Izdano: American Society for Biochemistry and Molecular Biology 2019
Teme:
Metabolism
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6690701/
https://ncbi.nlm.nih.gov/pubmed/31213529
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA119.009442
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