Structural basis for substrate selectivity and nucleophilic substitution mechanisms in human adenine phosphoribosyltransferase catalyzed reaction

The reversible adenine phosphoribosyltransferase enzyme (APRT) is essential for purine homeostasis in prokaryotes and eukaryotes. In humans, APRT (hAPRT) is the only enzyme known to produce AMP in cells from dietary adenine. APRT can also process adenine analogs, which are involved in plant developm...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Ozeir, Mohammad, Huyet, Jessica, Burgevin, Marie-Claude, Pinson, Benoît, Chesney, Françoise, Remy, Jean-Marc, Siddiqi, Abdul Rauf, Lupoli, Roland, Pinon, Grégory, Saint-Marc, Christelle, Gibert, Jean-François, Morales, Renaud, Ceballos-Picot, Irène, Barouki, Robert, Daignan-Fornier, Bertrand, Olivier-Bandini, Anne, Augé, Franck, Nioche, Pierre
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2019
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6690681/
https://ncbi.nlm.nih.gov/pubmed/31160323
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA119.009087
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