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Creation of the 5-hydroxytryptamine receptor 7 knockout rat as a tool for cardiovascular research
Using CRISPR-Cas9 technology, we created a 5-HT(7) receptor global knockout (KO) rat, on a Sprague-Dawley background, for use in cardiovascular physiology studies focused on blood pressure regulation. A stable line carrying indels in exons 1 and 2 of the rat Htr7 locus was established and validated....
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| Pubblicato in: | Physiol Genomics |
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| Autori principali: | , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
American Physiological Society
2019
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6689730/ https://ncbi.nlm.nih.gov/pubmed/31125290 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/physiolgenomics.00030.2019 |
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