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Aβ42 fibril formation from predominantly oligomeric samples suggests a link between oligomer heterogeneity and fibril polymorphism

Amyloid-β (Aβ) oligomers play a central role in the pathogenesis of Alzheimer's disease. Oligomers of different sizes, morphology and structures have been reported in both in vivo and in vitro studies, but there is a general lack of understanding about where to place these oligomers in the over...

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Détails bibliographiques
Publié dans:R Soc Open Sci
Auteurs principaux: Xue, Christine, Tran, Joyce, Wang, Hongsu, Park, Giovanna, Hsu, Frederick, Guo, Zhefeng
Format: Artigo
Langue:Inglês
Publié: The Royal Society 2019
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6689619/
https://ncbi.nlm.nih.gov/pubmed/31417723
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1098/rsos.190179
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