Knockout of latrophilin-3 in Sprague-Dawley rats causes hyperactivity, hyper-reactivity, under-response to amphetamine, and disrupted dopamine markers

Attention deficit hyperactivity disorder is a pervasive developmental disorder characterized by inattention, impulsivity, and hyperactivity and is 75–90% heritable. Latrophilin-3 (LPHN3; or ADGRL(3) is associated with a subtype of ADHD, but how it translates to symptoms is unknown. LPHN3 is a synapt...

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Veröffentlicht in:Neurobiol Dis
Hauptverfasser: Regan, Samantha L., Hufgard, Jillian R., Pitzer, Emily M., Sugimoto, Chiho, Hu, Yueh-Chiang, Williams, Michael T., Vorhees, Charles V.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2019
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6689430/
https://ncbi.nlm.nih.gov/pubmed/31176715
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.nbd.2019.104494
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