3′ UTR shortening represses tumor-suppressor genes in trans by disrupting ceRNA crosstalk

Widespread mRNA 3′ UTR shortening through alternative polyadenylation(1) promotes tumor growth in vivo(2). A prevailing hypothesis is that it induces proto-oncogene expression in cis through escaping microRNA-mediated repression. Here we report a surprising enrichment of 3′UTR shortening among trans...

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Udgivet i:Nat Genet
Main Authors: Park, Hyun Jung, Ji, Ping, Kim, Soyeon, Xia, Zheng, Rodriguez, Benjamin, Li, Lei, Su, Jianzhong, Chen, Kaifu, Masamha, Chioniso P., Baillat, David, Fontes-Garfias, Camila R., Shyu, Ann-Bin, Neilson, Joel R., Wagner, Eric J., Li, Wei
Format: Artigo
Sprog:Inglês
Udgivet: 2018
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6689271/
https://ncbi.nlm.nih.gov/pubmed/29785014
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41588-018-0118-8
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