A case report of clonal EBV-like memory CD4+ T cell activation in fatal checkpoint inhibitor-induced encephalitis

Checkpoint inhibitors produce durable responses in numerous metastatic cancers, but immune-related adverse events (irAEs) complicate and limit their benefit. IrAEs can affect organ systems idiosyncratically; presentations range from mild and self-limited to fulminant and fatal. The molecular mechani...

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Αποθηκεύτηκε σε:
Λεπτομέρειες βιβλιογραφικής εγγραφής
Τόπος έκδοσης:Nat Med
Κύριοι συγγραφείς: Johnson, Douglas B., McDonnell, Wyatt J., Ericsson-Gonzalez, Paula I., Al-Rohil, Rami, Mobley, Bret C., Salem, Joe-Elie, Wang, Daniel Y., Sanchez, Violeta, Wang, Yu, Chastain, Cody A., Barker, Kristi, Liang, Yan, Warren, Sarah, Beechem, Joseph, Menzies, Alexander M., Tio, Martin, Long, Georgina V., Cohen, Justine V., Guidon, Amanda C., O’Hare, Méabh, Chandra, Sunandana, Chowdhary, Akansha, Lebrun-Vignes, Benedicte, Goldinger, Simone, Rushing, Elisabeth, Buchbinder, Elizabeth, Mallal, Simon A., Shi, Chanjuan, Xu, Yaomin, Moslehi, Javid J., Sanders, Melinda E., Sosman, Jeffrey A., Balko, Justin M.
Μορφή: Artigo
Γλώσσα:Inglês
Έκδοση: 2019
Θέματα:
Article
Διαθέσιμο Online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6689251/
https://ncbi.nlm.nih.gov/pubmed/31332390
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41591-019-0523-2
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