Development of a new fusion-enhanced oncolytic immunotherapy platform based on herpes simplex virus type 1

BACKGROUND: Oncolytic viruses preferentially replicate in tumors as compared to normal tissue and promote immunogenic cell death and induction of host systemic anti-tumor immunity. HSV-1 was chosen for further development as an oncolytic immunotherapy in this study as it is highly lytic, infects hum...

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Bibliografiske detaljer
Udgivet i:J Immunother Cancer
Main Authors: Thomas, Suzanne, Kuncheria, Linta, Roulstone, Victoria, Kyula, Joan N., Mansfield, David, Bommareddy, Praveen K., Smith, Henry, Kaufman, Howard L., Harrington, Kevin J., Coffin, Robert S.
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2019
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6689178/
https://ncbi.nlm.nih.gov/pubmed/31399043
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40425-019-0682-1
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