PERINATAL DIAZINON EXPOSURE COMPROMISES THE DEVELOPMENT OF ACETYLCHOLINE AND SEROTONIN SYSTEMS

Organophosphate pesticides are developmental neurotoxicants. We gave diazinon via osmotic minipumps implanted into dams prior to conception, with exposure continued into the second postnatal week, at doses (0.5 or 1 mg/kg/day) that did not produce detectable brain cholinesterase inhibition. We evalu...

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Veröffentlicht in:Toxicology
Hauptverfasser: Slotkin, Theodore A., Skavicus, Samantha, Ko, Ashley, Levin, Edward D., Seidler, Frederic J.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2019
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6689134/
https://ncbi.nlm.nih.gov/pubmed/31251962
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.tox.2019.152240
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