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Immunodeficiency and Epstein Barr virus induced lymphoproliferation caused by 4-1BB deficiency
BACKGROUND: The tumor necrosis family factor receptor (TNFR) family member 4-1BB (CD137) is encoded by TNFRSF9 and expressed on activated T cells. 4-1BB provides a co-stimulatory signal that enhances CD8(+) T cell survival, cytotoxicity, and mitochondrial activity, thereby promoting immunity against...
Enregistré dans:
| Publié dans: | J Allergy Clin Immunol |
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| Auteurs principaux: | , , , , , , , , , , , , , , , , , , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
2019
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6688916/ https://ncbi.nlm.nih.gov/pubmed/30872117 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jaci.2019.03.002 |
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