Immunodeficiency and Epstein Barr virus induced lymphoproliferation caused by 4-1BB deficiency

BACKGROUND: The tumor necrosis family factor receptor (TNFR) family member 4-1BB (CD137) is encoded by TNFRSF9 and expressed on activated T cells. 4-1BB provides a co-stimulatory signal that enhances CD8(+) T cell survival, cytotoxicity, and mitochondrial activity, thereby promoting immunity against...

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Gepubliceerd in:J Allergy Clin Immunol
Hoofdauteurs: Alosaimi, Mohammed, Hoenig, Manfred, Jaber, Faris, Platt, Craig D., Jones, Jennifer, Wallace, Jacqueline, Debatin, Klaus-Michael, Schulz, Ansgar, Jacobsen, Eva, Möller, Peter, Shamseldin, Hanan E., Abdulwahab, Ferdous, Ibrahim, Niema, Alardati, Hosam, Almuhizi, Faisal, Abosoudah, Ibraheem F., Basha, Talal A., Chou, Janet, Alkuraya, Fowzan S., Geha, Raif S.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2019
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6688916/
https://ncbi.nlm.nih.gov/pubmed/30872117
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jaci.2019.03.002
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