IgM Antibodies Can Access Cryptic Antigens Denied to IgG: Hypothesis on Novel Binding Mechanism

Antibodies are well-known protein mediators of immunity. IgM is the primordial member and the neglected sibling of the later-evolved and more proficient IgG in regard to their therapeutic and diagnostic use. Serendipitously, however, we found a paradox: While murine IgM antibodies specific for guano...

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Detalhes bibliográficos
Publicado no:Front Immunol
Main Authors: Law, Eric Chun Yiu, Leung, Danny Tze Ming, Tam, Frankie Chi Hang, Cheung, Kitty Kit Ting, Cheng, Naomi Hua Yin, Lim, Pak Leong
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2019
Assuntos:
Immunology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6688401/
https://ncbi.nlm.nih.gov/pubmed/31428101
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2019.01820
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