Role of KRAS in regulating normal human airway basal cell differentiation

BACKGROUND: KRAS is a GTPase that activates pathways involved in cell growth, differentiation and survival. In normal cells, KRAS-activity is tightly controlled, but with specific mutations, the KRAS protein is persistently activated, giving cells a growth advantage resulting in cancer. While a grea...

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Dettagli Bibliografici
Pubblicato in:Respir Res
Autori principali: Ogawa, Fumihiro, Walters, Matthew S., Shafquat, Afrah, O’Beirne, Sarah L., Kaner, Robert J., Mezey, Jason G., Zhang, Haijun, Leopold, Philip L., Crystal, Ronald G.
Natura: Artigo
Lingua:Inglês
Pubblicazione: BioMed Central 2019
Soggetti:
Research
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6688249/
https://ncbi.nlm.nih.gov/pubmed/31399087
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12931-019-1129-4
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