The Caspase Inhibitor Z-VAD-FMK Alleviates Endotoxic Shock via Inducing Macrophages Necroptosis and Promoting MDSCs-Mediated Inhibition of Macrophages Activation

Macrophages play a critical role in the pathogenesis of endotoxin shock by producing excessive amounts of pro-inflammatory cytokines. A pan-caspase inhibitor, zVAD, can be used to induce necroptosis under certain stimuli. The role of zVAD in both regulating the survival and activation of macrophages...

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Bibliographic Details
Published in:Front Immunol
Main Authors: Li, Xuehui, Yao, Xiaoying, Zhu, Yuzhen, Zhang, Hui, Wang, Haiyan, Ma, Qun, Yan, Fenglian, Yang, Yonghong, Zhang, Junfeng, Shi, Hui, Ning, Zhaochen, Dai, Jun, Li, Zhihua, Li, Chunxia, Su, Fei, Xue, Yin, Meng, Xiangzhi, Dong, Guanjun, Xiong, Huabao
Format: Artigo
Language:Inglês
Published: Frontiers Media S.A. 2019
Subjects:
Immunology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6687755/
https://ncbi.nlm.nih.gov/pubmed/31428103
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2019.01824
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