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Noncanonical mechanism of voltage sensor coupling to pore revealed by tandem dimers of Shaker
In voltage-gated potassium channels (VGKC), voltage sensors (VSD) endow voltage-sensitivity to pore domains (PDs) through a not fully understood mechanism. Shaker-like VGKC show domain-swapped configuration: VSD of one subunit is covalently connected to its PD by the protein backbone (far connection...
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| Publicado no: | Nat Commun |
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| Main Authors: | , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group UK
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6687735/ https://ncbi.nlm.nih.gov/pubmed/31395867 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-11545-7 |
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