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Improved Modeling of Peptidic Foldamers Using a Quantum Chemical Parametrization Based on Torsional Minimum Energy Path Matching

The increasing interest in novel foldamer constructs demands an accurate computational treatment on an extensive timescale. However, it is still a challenge to derive a force field (FF) that can reproduce the experimentally known fold while also allowing the spontaneous exploration of other structur...

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Publicado en:Chempluschem
Main Authors: Wacha, András, Beke‐Somfai, Tamás, Nagy, Tibor
Formato: Artigo
Idioma:Inglês
Publicado: John Wiley and Sons Inc. 2019
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6686720/
https://ncbi.nlm.nih.gov/pubmed/31423411
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cplu.201900180
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