Differentiating Isomeric Deprotonated Glucuronide Drug Metabolites via Ion/Molecule Reactions in Tandem Mass Spectrometry

Isomeric O- and N-glucuronides are common drug metabolites produced in phase II of drug metabolism. Distinguishing these isomers by using common analytical techniques has proven challenging. A tandem mass spectrometric method based on gas-phase ion/molecule reactions of deprotonated glucuronide drug...

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Detalhes bibliográficos
Publicado no:Anal Chem
Main Authors: Kong, John Y., Yu, Zaikuan, Easton, Mckay W., Niyonsaba, Edouard, Ma, Xin, Yerabolu, Ravikiran, Sheng, Huaming, Jarrell, Tiffany M., Zhang, Zhoupeng, Ghosh, Arun K., Kenttämaa, Hilkka I.
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6686676/
https://ncbi.nlm.nih.gov/pubmed/29984992
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.analchem.8b02083
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