Endoplasmic reticulum stress disrupts lysosomal homeostasis and induces blockade of autophagic flux in human trophoblasts

Pregnancy is a stress factor culminating into mild endoplasmic reticulum (ER) stress, which is necessary for placental development. However, excessive or chronic ER stress in pre-eclamptic placentas leads to placental dysfunction. The precise mechanisms through which excessive ER stress impacts trop...

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Publicado en:Sci Rep
Autores principales: Nakashima, Akitoshi, Cheng, Shi-Bin, Kusabiraki, Tae, Motomura, Kenichiro, Aoki, Aiko, Ushijima, Akemi, Ono, Yosuke, Tsuda, Sayaka, Shima, Tomoko, Yoshino, Osamu, Sago, Haruhiko, Matsumoto, Kenji, Sharma, Surendra, Saito, Shigeru
Formato: Artigo
Lenguaje:Inglês
Publicado: Nature Publishing Group UK 2019
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6685987/
https://ncbi.nlm.nih.gov/pubmed/31391477
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-47607-5
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