Proteolysis of the low density lipoprotein receptor by bone morphogenetic protein-1 regulates cellular cholesterol uptake

The development of cardiovascular disease is intimately linked to elevated levels of low-density lipoprotein (LDL) cholesterol in the blood. Hepatic LDL receptor (LDLR) levels regulate the amount of plasma LDL. We identified the secreted zinc metalloproteinase, bone morphogenetic protein 1 (BMP1), a...

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Publicado no:Sci Rep
Main Authors: Banerjee, Sreemoti, Andrew, Robert J., Duff, Christopher J., Fisher, Kate, Jackson, Carolyn D., Lawrence, Catherine B., Maeda, Nobuyo, Greenspan, Daniel S., Kellett, Katherine A. B., Hooper, Nigel M.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6684651/
https://ncbi.nlm.nih.gov/pubmed/31388055
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-47814-0
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