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Pancreatic (pro)enzymes treatment suppresses BXPC-3 pancreatic Cancer Stem Cell subpopulation and impairs tumour engrafting

Cancer stem cells (CSCs) subpopulation within the tumour is responsible for metastasis and cancer relapse. Here we investigate in vitro and in vivo the effects of a pancreatic (pro)enzyme mixture composed of Chymotrypsinogen and Trypsinogen (PRP) on CSCs derived from a human pancreatic cell line, Bx...

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Publicat a:Sci Rep
Autors principals: Hernández-Camarero, Pablo, López-Ruiz, Elena, Griñán-Lisón, Carmen, García, María Ángel, Chocarro-Wrona, Carlos, Marchal, Juan Antonio, Kenyon, Julian, Perán, Macarena
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group UK 2019
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6684636/
https://ncbi.nlm.nih.gov/pubmed/31388092
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-47837-7
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