Kinesin-5 promotes microtubule nucleation and assembly by stabilizing a lattice-competent conformation of tubulin

Besides sliding apart antiparallel microtubules during spindle elongation, the mitotic kinesin-5, Eg5 promotes microtubule polymerization, emphasizing its importance in mitotic spindle length control. Here, we characterize the Eg5 microtubule polymerase mechanism by assessing motor-induced changes i...

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Bibliographic Details
Published in:Curr Biol
Main Authors: Chen, Geng-Yuan, Cleary, Joseph M., Asenjo, Ana B., Chen, Yalei, Mascaro, Jacob A., Arginteanu, David F. J., Sosa, Hernando, Hancock, William O.
Format: Artigo
Language:Inglês
Published: 2019
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6684259/
https://ncbi.nlm.nih.gov/pubmed/31280993
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cub.2019.05.075
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