Rapid Aldosterone-Mediated Signaling in the DCT Increases Activity of the Thiazide-Sensitive NaCl Cotransporter

BACKGROUND: The NaCl cotransporter NCC in the kidney distal convoluted tubule (DCT) regulates urinary NaCl excretion and BP. Aldosterone increases NaCl reabsorption via NCC over the long-term by altering gene expression. But the acute effects of aldosterone in the DCT are less well understood. METHO...

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Foilsithe in:J Am Soc Nephrol
Main Authors: Cheng, Lei, Poulsen, Søren Brandt, Wu, Qi, Esteva-Font, Cristina, Olesen, Emma T. B., Peng, Li, Olde, Björn, Leeb-Lundberg, L. M. Fredrik, Pisitkun, Trairak, Rieg, Timo, Dimke, Henrik, Fenton, Robert A.
Formáid: Artigo
Teanga:Inglês
Foilsithe: American Society of Nephrology 2019
Ábhair:
Basic Research
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6683706/
https://ncbi.nlm.nih.gov/pubmed/31253651
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1681/ASN.2018101025
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