Nanoparticles With a Specific Size and Surface Charge Promote Disruption of the Secondary Structure and Amyloid-Like Fibrillation of Human Insulin Under Physiological Conditions

Nanoparticles attract much interest as fluorescent labels for diagnostic and therapeutic tools, although their applications are often hindered by size- and shape-dependent cytotoxicity. This cytotoxicity is related not only to the leak of toxic metals from nanoparticles into a biological solution, b...

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Detalhes bibliográficos
Publicado no:Front Chem
Main Authors: Sukhanova, Alyona, Poly, Simon, Bozrova, Svetlana, Lambert, Éléonore, Ewald, Maxime, Karaulov, Alexander, Molinari, Michael, Nabiev, Igor
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2019
Assuntos:
Chemistry
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6683663/
https://ncbi.nlm.nih.gov/pubmed/31417892
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fchem.2019.00480
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