The neuropeptide GsMTx4 inhibits a mechanosensitive BK channel through the voltage-dependent modification specific to mechano-gating

The cardiac mechanosensitive BK (Slo1) channels are gated by Ca(2+), voltage, and membrane stretch. The neuropeptide GsMTx4 is a selective inhibitor of mechanosensitive (MS) channels. It has been reported to suppress stretch-induced cardiac fibrillation in the heart, but the mechanism underlying the...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Li, Hui, Xu, Jie, Shen, Zhong-Shan, Wang, Guang-Ming, Tang, Mingxi, Du, Xiang-Rong, Lv, Yan-Tian, Wang, Jing-Jing, Zhang, Fei-Fei, Qi, Zhi, Zhang, Zhe, Sokabe, Masahiro, Tang, Qiong-Yao
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2019
Assuntos:
Molecular Biophysics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6682741/
https://ncbi.nlm.nih.gov/pubmed/31201274
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA118.005511
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