The Developmental Neurotoxicity of Tobacco Smoke Can Be Mimicked by a Combination of Nicotine and Benzo[a]Pyrene: Effects on Cholinergic and Serotonergic Systems

Tobacco smoke contains polycyclic aromatic hydrocarbons (PAHs) in addition to nicotine. We compared the developmental neurotoxicity of nicotine to that of the PAH archetype, benzo[a]pyrene (BaP), and also evaluated the effects of combined exposure to assess whether PAHs might exacerbate the adverse...

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Veröffentlicht in:Toxicol Sci
Hauptverfasser: Slotkin, Theodore A, Skavicus, Samantha, Ko, Ashley, Levin, Edward D, Seidler, Frederic J
Format: Artigo
Sprache:Inglês
Veröffentlicht: Oxford University Press 2019
Schlagworte:
Nicotine and Benzo[apyrene] Mimic Development Neurotoxicity of Tobacco Smoke
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6681680/
https://ncbi.nlm.nih.gov/pubmed/30247698
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/toxsci/kfy241
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